Based in Mumbai, the films follows Munna Bhai (Sanjay Dutt), a goon who tries to please his father (Sunil Dutt) by pretending to be a physician. When a doctor, Asthana (Irani), exposes Munna's lies and tarnishes his father's honour, Munna enrols in a medical college. Hijinks ensue when Munna, upon finding that Asthana is the college's dean, vows revenge, while also sparking a romance with a house doctor, Suman (Singh), unaware that she is Asthana's daughter.

Munna Bhai M.B.B.S. was a major critical and commercial success, and was later followed by a second film Lage Raho Munna Bhai (2006), thus becoming the first installment of the Munna Bhai film series. The film went on to win the 2004 National Film Award for Best Popular Film, and several Filmfare awards, including the Best Film (Critics) and Best Screenplay. At the box office, it achieved a silver jubilee status (25-week run) being one of only eight Hindi films to have achieved this status since the year 2000.^[3] In its 26th week of release, the film could still be found playing on 300 screens throughout India.^[4]

Hirani revealed in an interview in September 2019 that production on the third Munna Bhai film starring Dutt in the title role will begin in towards the end of 2020.

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